Docking studies, synthesis, characterization, and cytotoxicity activity of new bis-chalcones derivatives

Introduction: A bis-chalcones were prepared by the reaction of terephthalaldehyde with 3-acetyl-2,5-dichlorothiophene or 3-acetyl- 5-chlorothiophene and cyclo ketone derivatives phenyl aldehyde in good yields.
 Methods: The molecular docking studies conducted using Discovery Studio (DSv4.5) MG. Tools installed Window 10. cancer receptor (3ERT) was downloaded from protein data bank (PDB). All new compounds characterized IR, 1H-NMR, 13C-NMR, 2D-NMR, CHN elemental analysis. anticancer activity synthesized determined MTT (3-(4, 5- dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide) reduction assay against MCF-7 cells, then minimum inhibitory concentration (IC50) reference standard drug tamoxifen.
 Results: results showed that compound 6 more potent inhibiting growth on both types compared to